The Brain-Gut-Microbiome Axis

Introduction: The presence of neurons in the gut, although smaller amount than brain, is sufficient for formation a proper and autonomous nervous system, independent central system called Enteric Nervous System (ENS). Through production substances such as serotonin, capable transmitting impulses throughout body, an efficient communication created between intestine brain through vagus nerve (VN). third element this connection microbiome or intestinal flora, important digestion protection organism from infections. Here we describe complex mediators brain-gutmicrobiome- mmune-neural-endocrine connection. Discussion: brain-gut-microbiome axis has several types well-established connections. Alteration any those connections systems immediately will reflect axis, generating alterations gut function microbiome. disruption related to diseases. Conclusion: Some measures can be taken prophylactically prevent establishment diseases microbiome, exclusive breastfeeding avoid excessive hygiene cow’s milk early life. must done inflammations that transform neuron target organ start immune reactions brain.